Synthesis of 4-hydroxy-1-methyl-4-(2-furyl)-3-(2- furylhydroxymethyl) piperidine and Transformation into perhydro[1,3,2]dioxaborinino[5,4-c]pyridine
Authors: Nguyen, Thi Thanh Phuong
Tran, Thi Thanh Van
Le, Tuan Anh
Truong, Hong HIeu
Tran, Thach Van
Having been synthesized successfully heterocyclic system, namely 2-aryl-N-methyl-4,8a-di(α-furyl)perhydro[1,2,3]dioxaborinino-[5,4-c]pyridine contains two piperidine and dioxaborinine rings. This new heterocyclic system was prepared from the reaction of N-methyl-3-(α-hydroxyfuryl)-4-(α-furyl)-γ-piperidol and some derivatives of arylboronic acid. The structure of new substances was confirmed by physical-chemical method including 1Н NMR, IR, MS. Futhermore, PASS online Program investigated that di(α-furyl)perhydro[1,2,3]dioxaborinino-[5,4-c]pyridine derivatives have high potential of bioactivities such as dermatology, spasmology, anticoagulant and antipsoriatic agent … which promote us to develop the new method affording this kind of compounds....
| Title: | Synthesis of 4-hydroxy-1-methyl-4-(2-furyl)-3-(2- furylhydroxymethyl) piperidine and Transformation into perhydro[1,3,2]dioxaborinino[5,4-c]pyridine |
| Authors: | Nguyen, Thi Thanh Phuong Tran, Thi Thanh Van Le, Tuan Anh Truong, Hong HIeu Tran, Thach Van ... |
| Keywords: | piperidine;dioxaborinine;Mannich reaction;multicomponent condensation reaction;azacrown ether |
| Issue Date: | 2017 |
| Publisher: | ĐHQGHN |
| Series/Report no.: | Tập 33;Số 3 |
| Description: | tr. 98-104 |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/60786 |
| ISSN: | 2588-1140 |
| Appears in Collections: | Natural Sciences and Technology |
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